FGFR1 (837-852) Goat Polyclonal Antibody

CAT#: AP22518PU-N

FGFR1 (837-852) goat polyclonal antibody, Aff - Purified

Product Images

Antibody (0.3 ug/ml) staining of human breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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  Human Kidney (formalin-fixed, paraffin-embedded) stained with FGFR1 antibody at 4 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Small Intestine (formalin-fixed, paraffin-embedded) stained with FGFR1 antibody at 4 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/32000.
  Immunohistochemistry on Paraffin Sections: 4 µg/ml.
  Western Blot: 0.3 - 1 µg/ml.
• Reactivities: Bat, Bovine, Canine, Equine, Human, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-term of human FGFR1
• Specificity: This antibody detects CD331 / FGFR1 (C-term).
  It is expected to recognise five isoforms (as represented by NP_075598.2; NP_056934.2; NP_075593.1; NP_075594.1; NP_075599.1).
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 2
• Database Link:
  Entrez Gene 2260 Human
• Background: The fibroblast growth factor receptor 1 belongs to the FGF Receptor subfamily. The full-length protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Ligand binding results in the activation of a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Various isoforms of FGFR1 have been identified that differ in structure and specificity. Defects in FGFR1 cause craniofacial abnormalities in diseases such as Pfeiffer syndrome and Jackson-Weiss syndrome.
• Synonyms: BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, BFGFR, bFGF-R-1, FLT-2, N-sam, Proto-oncogene c-Fgr

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Adherens junction, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton