PIAS2 (431-445) Goat Polyclonal Antibody

CAT#: AP22538PU-N

PIAS2 (431-445) goat polyclonal antibody, Aff - Purified

Product Images

Human Kidney (formalin-fixed, paraffin-embedded) stained with PIAS2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Prostate (formalin-fixed, paraffin-embedded) stained with PIAS2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Testis (formalin-fixed, paraffin-embedded) stained with PIAS2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/8000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Bat, Canine, Equine, Human, Rabbit
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human PIAS2
• Specificity: This antibody detects PIAS2 (Internal).
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens protein inhibitor of activated STAT 2 (PIAS2), transcript variant beta
• Database Link:
  Entrez Gene 17344 MouseEntrez Gene 83422 RatEntrez Gene 9063 Human
• Background: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied.
• Synonyms: PIASX, ARIP3, DAB2-interacting protein, DIP, Miz1, PIAS-NY protein

Reference Data

• Protein Families: Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis