CXCR4 (14-40) Goat Polyclonal Antibody
Other products for "CXCR4"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA: 1/25000. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/500. |
Reactivities | Human, Mouse |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Sequence corresponding to the N-terminal extracellular domain of Mouse CXCR4 receptor. Epitope: aa14-40 |
Specificity | This antibody binds to CXCR4 receptor on Mouse spleen leukocytes as determined by Immunocytochemistry. |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 1 mg/ml BSA Preservative: 0.09% Sodium Azide |
Concentration | 1 mg/ml |
Purification | Immunoaffinity Chromatography |
Gene Name | Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1 |
Database Link | |
Background | CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing. |
Synonyms | CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
Protein Pathways | Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration |
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