CXCR4 (14-40) Goat Polyclonal Antibody

CAT#: AP22560PU-N

CXCR4 (14-40) goat polyclonal antibody, Aff - Purified

Product Images

Human Kidney (formalin-fixed, paraffin-embedded) stained with CXCR4 antibody at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Spleen (formalin-fixed, paraffin-embedded) stained with CXCR4 antibody at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Testis (formalin-fixed, paraffin-embedded) stained with CXCR4 antibody at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/25000.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500.
• Reactivities: Human, Mouse
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Sequence corresponding to the N-terminal extracellular domain of Mouse CXCR4 receptor. Epitope: aa14-40
• Specificity: This antibody binds to CXCR4 receptor on Mouse spleen leukocytes as determined by Immunocytochemistry.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Stabilizer: 1 mg/ml BSA
  Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1
• Database Link:
  Entrez Gene 12767 MouseEntrez Gene 60628 RatEntrez Gene 707329 MonkeyEntrez Gene 7852 Human
• Background: CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing.
• Synonyms: CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration