Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody

CAT#: AP22626PU-N

Tyrosine Hydroxylase (TH) rabbit polyclonal antibody, Purified

Product Images

Western blot of rat caudate lysate should specific immunolabeling of the ~60k Tyrosine Hydroxylase protein.

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  Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.

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  Human Heart, Nerve (formalin-fixed, paraffin-embedded) stained with TH antibody AP22626PU-N at 1/100 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunofluorescence: 1/1000.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 1/100.
  Western Blot: 1/1000.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: TH antibody was raised against sDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma
• Specificity: This antibody reacts to Tyrosine Hydroxylase (TH).
• Formulation: 50 µL of 10 mM HEPES, pH 7.5 containing 150 mM sodium chloride, 0.1 mg/mL BSA, 50% glycerol.
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens tyrosine hydroxylase (TH), transcript variant 2
• Database Link:
  Entrez Gene 25085 RatEntrez Gene 7054 Human
• Background: Tyrosine hydroxylase in involved in the conversion of phenylalanine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines and as such has a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript. Expression of the mRNAs varies in different parts of the nervous system. Defects in TH are the cause of autosomal recessive Segawa syndrome.
• Synonyms: Tyrosine 3-hydroxylase, TYH

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Parkinson's disease, Tyrosine metabolism