Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

CAT#: AP22661PU-N

Angiotensin Converting Enzyme 2 (ACE2) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of ACE2 in human kidney lysate with ACE2 antibody at 2 ug/ml.

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  Human Kidney (formalin-fixed, paraffin-embedded) stained with ACE2 antibody at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Testis (formalin-fixed, paraffin-embedded) stained with ACE2 antibody at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot: 0.5 - 2 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: ACE2 antibody was raised against synthetic peptide
• Specificity: This antibody reacts to Angiotensin I Converting Enzyme 2 (ACE2).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens angiotensin I converting enzyme 2 (ACE2)
• Database Link:
  Entrez Gene 59272 Human
• Background: Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
• Synonyms: Angiotensin-converting enzyme 2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system