SIRT2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP22673PU-N

SIRT2 (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of SIRT2 in Mouse brain lysate with SIRT2 antibody at (A) 1 and (B) 2 ug/ml.

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  Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SIRT2 antibody at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Heart (formalin-fixed, paraffin-embedded) stained with SIRT2 antibody at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Placenta (formalin-fixed, paraffin-embedded) stained with SIRT2 antibody at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: SIRT2 antibody was raised against 19 amino acid peptide near the carboxy terminus of the Human SIRT2
• Specificity: This antibody detects SIRT2 / SIR2 at C-term.
• Formulation: PBS containing 0.02% Sodium Azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens sirtuin 2 (SIRT2), transcript variant 1
• Database Link:
  Entrez Gene 64383 MouseEntrez Gene 361532 RatEntrez Gene 22933 Human
• Background: The founding member of the sirtuin protein family was the silent information regulator 2 protein (Sir2p) of Saccharomyces cervisiae, an NAD+-dependent histone deacetylase (HDAC) that regulates chromatin silencing. The SIR2 family of genes are highly conserved from prokaryotes to eukaryotes. Mammals have seven homologs of Sir2p, SIRT1-7, which are involved in diverse processes ranging from transcriptional regulation, cell cycle progression and DNA-damage repair to aging. SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules and can deacetylate ?-tubulin and regulate progression through the cell cycle. Most Sirtuins are highly expressed in brain and testis, while Sirt2 expression is higher in fetal relative to adult brain. Recent studies on SIRT2 support the therapeutic utility of inhibitors for the treatment of neurodegenerative diseases such as Parkinson's disease.
• Synonyms: SIRT-2, SIR2-like protein 2, SIR2L, SIR2L2, sirtuin type 2, sirtuin 2, sirtuin-2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors