MET (C-term) Rabbit Polyclonal Antibody

CAT#: AP22713PU-N

MET (C-term) rabbit polyclonal antibody, Purified

Product Images

Human ovarian ca. stained with anti-c-Met

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  Human Liver (formalin-fixed, paraffin-embedded) stained with c-Met antibody at 15 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Placenta (formalin-fixed, paraffin-embedded) stained with c-Met antibody at 15 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 15 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: MET antibody was raised against a synthetic peptide from C-terminus of human c-Met protein
• Specificity: This antibody reacts to Hepatocyte Growth Factor Receptor (MET).
• Formulation: 10mM PBS/1% BSA buffer pH 7.4 with 0.09% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant 2
• Database Link:
  Entrez Gene 4233 Human
• Background: Met, an HGF Receptor/Met type protein kinase, is a cell-surface proto-oncogene that mediates the biological activities of hepatocyte growth factor. The protein is a disulfide-linked heterodimer comprised of two subunits: a 50 kD extracellular alpha subunit and a membrane-spanning 145 kD beta subunit that binds ligand. Met is an important regulator of cell proliferation and differentiation, organ regeneration, embryogenesis, and tumorogenesis. Constitutive activation mutations of the met gene lead to many cancers, particularly renal papillary carcinoma.
• Synonyms: Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma