Caspase 1 (CASP1) Rabbit Polyclonal Antibody

CAT#: AP22755PU-N

Caspase 1 (CASP1) rabbit polyclonal antibody, Purified

Product Images

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with CASP1 antibody AP22755PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/50.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: CASP1 antibody was raised against a synthetic peptide from the second quarter of human Caspase 1 protein
• Specificity: This antibody reacts to Caspase 1 (CASP1).
• Formulation: 10 mM PBS, pH 7.4 with 1% BSA and 0.09% Sodium Azide
  
  
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 1 (CASP1), transcript variant beta
• Database Link:
  Entrez Gene 12362 MouseEntrez Gene 25166 RatEntrez Gene 834 Human
• Background: Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.
• Synonyms: CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway