SMURF1 (66-96) Rabbit Polyclonal Antibody

CAT#: AP22777PU-N

SMURF1 (66-96) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis in mouse kidney tissue lysate (35 ug/lane).

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  Human Testis (formalin-fixed, paraffin-embedded) stained with SMURF1 antibody AP22777PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: SMURF1 antibody was raised against kLH conjugated synthetic peptide selected from the N-terminal region of human SMURF1 (aa 66-96).
• Specificity: This antibody reacts to Smad Ubiquitination Regulatory Factor 1 (SMURF1).
• Formulation: PBS containing 0.09% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Ammonium sulfate precipitation
• Gene Name: Homo sapiens SMAD specific E3 ubiquitin protein ligase 1 (SMURF1), transcript variant 1
• Database Link:
  Entrez Gene 75788 MouseEntrez Gene 57154 Human
• Background: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.
• Synonyms: SMURF 1, SMURF-1, KIAA1625

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis