PIM3 (C-term) Rabbit Polyclonal Antibody

CAT#: AP22788PU-N

PIM3 (C-term) rabbit polyclonal antibody, Purified

Product Images

AP22788PU-N is used in Western blot to detect PIM3 in mouse kidney tissue lysate.

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  Human Spleen (formalin-fixed, paraffin-embedded) stained with PIM3 antibody AP22788PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 259-288 amino acids from the C-terminal region of human PIM3.
• Specificity: This antibody reacts to Proto-Oncogene Serine/Threonine Protein Kinase PIM-3 (KID-1) (PIM3).
• Formulation: PBS containing 0.09% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Ammonium sulfate precipitation
• Gene Name: Homo sapiens Pim-3 proto-oncogene, serine/threonine kinase (PIM3)
• Database Link:
  Entrez Gene 223775 MouseEntrez Gene 415116 Human
• Background: KID-1 is an immediate early gene in the PIM protein kinase subfamily. KID-1 is induced by depolarization in PC12 cells and in brain. In brain, KID-1 expression is induced after generalized seizures and is limited to specific areas of the hippocampus and temporal lobe. The PIM kinases are important mediators of the neuronal plasticity following synaptic activity, which is necessary for brain development and for learning and memory. The PIM kinases are induced by membrane depolarization, which results in the activation of the Ca2+/calmodulin kinase- and adenylyl cyclase-dependent signal transduction pathways that are involved in the synaptic plasticity.
• Synonyms: PIM-3

Reference Data

• Protein Families: Druggable Genome, Protein Kinase