IRAK (IRAK1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP22789PU-N

IRAK (IRAK1) (C-term) rabbit polyclonal antibody, Purified

Product Images

(LEFT) Western blot analysis of IRAK1 in Jurkat cell lysate. IRAK1 (RIGHT) Western blot analysis of IRAK1 in 293 cell lysates (2 ug/lane) either non-transfected (Lane 1) or transiently transfected with the IRAK1 gene (Lane 2).

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  Human Placenta (formalin-fixed, paraffin-embedded) stained with IRAK1 antibody AP22789PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: IRAK1 antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human IRAK1.
• Specificity: This antibody reacts to Interleukin 1 Receptor-Associated Kinase 1 (IRAK1).
• Formulation: PBS containing 0.09% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein G Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 1 receptor associated kinase 1 (IRAK1), transcript variant 2
• Database Link:
  Entrez Gene 3654 Human
• Background: IRAK1, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK1 is recruited to the IL-1 receptor, phosphorylated and progressively degraded in response to IL-1 induction. The protein also has the ability to autophosphorylate. IRAK1 is immediately downstream of the MyD88 adapter protein and immediately upstream of TRAF6. IRAK1 (-/-) mice have impaired responses to interleukin-18. At least two mRNA transcript variants have been identified - 2.0 and 3.6 kb.
• Synonyms: IRAK-1, IRAK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway