CD146 (MCAM) Rabbit Polyclonal Antibody

CAT#: AP22800PU-N

CD146 (MCAM) rabbit polyclonal antibody, Purified

Product Images

Human Placenta (formalin-fixed, paraffin-embedded) stained with MCAM antibody followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y641 of human MCAM.
• Specificity: This antibody reacts to Melanoma Cell Adhesion Molecule (MCAM/MUC18).
• Formulation: PBS containing 0.09% sodium azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens melanoma cell adhesion molecule (MCAM)
• Database Link:
  Entrez Gene 4162 Human
• Background: MCAM (also termed CD146 or MUC18) is a cell-adhesion molecule belonging to the immunoglobulin gene superfamily. It mediates cell-cell interaction through heterophilic Mel-CAM/ligand adhesion. MCAM has been shown to expressed widely in normal and neoplastic human tissues. MUC18 expression is increased during prostate cancer initiation (high grade PIN) and progression to carcinoma, and in metastatic cell lines and metastatic carcinoma.
• Synonyms: MCAM, MUC18, CD146

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane