CCR3 (N-term) Rabbit Polyclonal Antibody

CAT#: AP22847PU-N

CCR3 (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of CCR3 in human spleen tissue lysates with CCR3 antibody (AP22847PU-N) at 1 (lane 1) and 2 ug/ml (lane 2), and 2 ug/ml in the presence of blocking peptide (lane 3).

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  Human Lung (formalin-fixed, paraffin-embedded) stained with CCR3 antibody AP22847PU-N at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 epsilon. ( N-TERMINAL )
• Specificity: This antibody reacts to C-C Chemokine Receptor 3 (CCR3).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 1
• Database Link:
  Entrez Gene 12771 MouseEntrez Gene 117027 RatEntrez Gene 1232 Human
• Background: CCR3, a Chemokine Receptor, was cloned from human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils ( Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain.
• Synonyms: C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction