FLIP (CFLAR) (191-209) Rabbit Polyclonal Antibody

CAT#: AP22849PU-N

FLIP (CFLAR) (191-209) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

Other products for "CFLAR"

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA.
Immunocytochemistry.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/1000.
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen CFLAR antibody was raised against synthetic peptide
Specificity This antibody reacts to CASP8 And FADD-like Apoptosis Regulator (CFLAR).
Formulation PBS containing 0.02% sodium azide.
State: Purified
State: Liquid purified Ig fraction
Concentration 1 mg/ml
Purification Immunoaffinity Chromatography
Gene Name Homo sapiens CASP8 and FADD like apoptosis regulator (CFLAR), transcript variant 2
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPa, b, g, and d, respectively.
Synonyms c-FLIP, CLARP, MRIT, CASH, FLAME-1, CASP8AP1, Usurpin
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways Apoptosis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.