Caspase 1 (CASP1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP22860PU-N

Caspase 1 (CASP1) (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of caspase-1 in human heart cell lysate with caspase-1 antibody (AP22860PU-N) at (A) 0.5, (B) 1, and (C) 2 ug/ml.

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  Human Heart (formalin-fixed, paraffin-embedded) stained with CASP1 antibody AP22860PU-N at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Testis (formalin-fixed, paraffin-embedded) stained with CASP1 antibody AP22860PU-N at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.5 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant rat HO-1 (Hsp32) lacking the membrane spanning region
• Specificity: This antibody reacts to Caspase 1 (CASP1).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 1 (CASP1), transcript variant beta
• Database Link:
  Entrez Gene 834 Human
• Background: Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.
• Synonyms: CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway