Caspase 1 (CASP1) Rabbit Polyclonal Antibody

CAT#: AP22861PU-N

Caspase 1 (CASP1) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 0.5 µg/ml.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen HT-29 colon carcinoma cell line.
Specificity This antibody reacts to Caspase 1 (CASP1).
Formulation PBS containing 0.02% sodium azide.
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens caspase 1 (CASP1), transcript variant beta
Background Caspase 1, also called interleukin-1 beta converting enzyme, is a cysteine C14 endopeptidase able to process pro-interleukin-1 beta into its active form. Caspase 1 is identical to Caenorhabditis elegans cell death gene ced-3 and may be involved in apoptotic signalling. Inhibition of caspase-1 in mice models extended survival and delayed appearance of neuronal inclusions and symptoms of Huntingdon disease.
Synonyms CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45
Reference Data
Protein Families Druggable Genome, Protease
Protein Pathways Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.