RPS6KA3 (604-617) Rabbit Polyclonal Antibody

CAT#: AP22881PU-N

RPS6KA3 (604-617) rabbit polyclonal antibody, Purified

Product Images

Human Pancreas (formalin-fixed, paraffin-embedded) stained with RPS6KA3 antibody followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Tonsil (formalin-fixed, paraffin-embedded) stained with RPS6KA3 antibody followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Immunoprecipitation.
  Western Blot: 1 µg/ml.
• Reactivities: Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide based on the mouse RSK2 S6 kinase (amino acids 604-617) with the cysteine (C) residue added and the peptide coupled to KLH
• Specificity: Detects an ~90 kD protein, corresponding to the apparent molecular mass of RSK2 on SDS-PAGE immunoblots.
• Formulation: PBS, pH 7.2 containing 50% Glycerol and 0.09% Azide
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
• Database Link:
  Entrez Gene 110651 MouseEntrez Gene 501560 RatEntrez Gene 6197 Human
• Background: RSK2, an RSK serine/threonine kinase, has been implicated in Coffin-Lowry syndrome, a disease characterized by cognitive impairment, characteristic facial and digital findings and skeletal anomalies.
• Synonyms: RSK-2, ISPK1, ISPK-1, MAPKAPK1, MAPKAPK-1b, S6K-alpha-3, p90RSK3, Ribosomal S6 kinase 2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Long-term potentiation, MAPK signaling pathway, mTOR signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation