Caspase 9 (CASP9) (299-318) Rabbit Polyclonal Antibody

CAT#: AP22914PU-N

Caspase 9 (CASP9) (299-318) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of caspase-9 in HeLa whole cell lysate with Caspase-9 antibody at 1/1000 dilution.

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunocytochemical staining of K562 cells using Caspase-9 antibody at 2 ug/ml.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/1000 - 1/2000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Akirin1 antibody was raised against peptide corresponding to aa 299-318 of the human Caspase 9.
• Specificity: This antibody reacts to Caspase 9 (CASP9).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 9 (CASP9), transcript variant alpha
• Database Link:
  Entrez Gene 842 Human
• Background: Caspase 9 is a cysteine C14 endopeptidase that mediates oncogene and drug-induced apoptosis. It is activated upon binding to Apaf-1/cytochrome c and inhibited upon phosphorylation by the serine/ threonine kinase Akt. Activated caspase-9 cleaves downstream caspases such as Caspase-3, -6 and -7 initiating the caspase cascade. Like other caspases, Caspase-9 plays a critical role in mediating apoptosis during normal brain development. Caspase-9 also cleaves amyloid beta-protein precursors, principal constituent of senile plaques, and is involved in neuronal death observed in Alzheimer disease.
• Synonyms: CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3

Reference Data

• Protein Families: Druggable Genome, Protease, Stem cell - Pluripotency
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis