AIF (AIFM1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP22915PU-N

AIF (AIFM1) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of AIF in K562 cell lysate with AIF antibody (AP22915PU-N) at 1 ug/ml.

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunocytochemistry of AIF in Jurkat cells with AIF antibody (AP22915PU-N) at 2 ug/ml.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.25 - 1 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Akirin1 antibody was raised against a 14 amino acid peptide near the center of the human Akirin1.
• Specificity: This antibody reacts to Apoptosis-inducing Factor (AIFM1, PDCD8).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Ion Exchange Chromatography
• Gene Name: Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 1
• Database Link:
  Entrez Gene 9131 Human
• Background: Caspase 9 is a cysteine C14 endopeptidase that mediates oncogene and drug-induced apoptosis. It is activated upon binding to Apaf-1/cytochrome c and inhibited upon phosphorylation by the serine/ threonine kinase Akt. Activated caspase-9 cleaves downstream caspases such as Caspase-3, -6 and -7 initiating the caspase cascade. Like other caspases, Caspase-9 plays a critical role in mediating apoptosis during normal brain development. Caspase-9 also cleaves amyloid beta-protein precursors, principal constituent of senile plaques, and is involved in neuronal death observed in Alzheimer disease.
• Synonyms: PDCD8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis