BACE2 (44-59) Rabbit Polyclonal Antibody

CAT#: AP22917PU-N

BACE2 (44-59) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.

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  Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.5 - 1 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: BACE2 antibody was raised against synthetic peptide (aptpgpgtpaerhadg) corresponding to amino acids 44 to 59 of human BACE2
• Specificity: This antibody reacts to Beta-site APP-cleaving Enzyme 2 (BACE2).
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a
• Database Link:
  Entrez Gene 56175 MouseEntrez Gene 288227 RatEntrez Gene 25825 Human
• Background: Accumulation of the amyloid-beta (alpha-beta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alpha-beta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within αβ (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alpha beta may also contribute to the pathogenesis of Down syndrome (6,7).
• Synonyms: Beta-secretase 2, AEPLC, ALP56, ASP21, Memapsin-1, Aspartic-like protease 56 kDa, Down region aspartic protease, ASP1

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease