ERp72 (PDIA4) (623-638) Rabbit Polyclonal Antibody

CAT#: AP22926PU-N

ERp72 (PDIA4) (623-638) rabbit polyclonal antibody, Purified

Product Images

Western Blot Analysis of ERp72: Lane 1: MW Marker Lane 2: Rat Liver Microsome Extract Lane 3: Mouse Liver Microsome Extract Lane 4: Human Liver Microsome Extract.

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  Brain, cerebellum, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Testis, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: PDIA4 antibody was raised against a synthetic peptide based on the sequence of mouse ERp72 (residues 623-638) with a cysteine residue added and coupled to KLH.
• Specificity: This antibody reacts to Protein Disulfide Isomerase Family A, Member 4 (PDIA4).
• Formulation: PBS containing 0.09% azide and 50% glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens protein disulfide isomerase family A member 4 (PDIA4)
• Database Link:
  Entrez Gene 12304 MouseEntrez Gene 116598 RatEntrez Gene 9601 Human
• Background: Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family1 that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.
• Synonyms: Protein disulfide-isomerase A4, Protein Disulfide Isomerase, ER protein 70, ERP70, ERp-70, ER protein 72, ERP72, ERp-72, ER marker

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vibrio cholerae infection