AIF (AIFM1) (593-606) Rabbit Polyclonal Antibody

CAT#: AP22931PU-N

AIF (AIFM1) (593-606) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of AIF in K562 cell lysate (A), mouse (B), and rat (C) liver tissue lysates with AIF antibody at 1 ug/ml.

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.25 - 1 µg/ml.
• Reactivities: Bovine, Bat, Canine, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: AIFM1 antibody was raised against synthetic peptide corresponding to amino acids 593 to 606 of human AIF
• Specificity: This antibody reacts to amino acids 593 to 606 of Apoptosis-inducing Factor (AIFM1, PDCD8).
• Formulation: PBS containing 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 1
• Database Link:
  Entrez Gene 26926 MouseEntrez Gene 83533 RatEntrez Gene 9131 Human
• Background: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.
• Synonyms: PDCD8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis