Caspase 4 (CASP4) (N-term) Rabbit Polyclonal Antibody

CAT#: AP22937PU-N

Caspase 4 (CASP4) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of caspase-4 in Ramos cells with caspase-4 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Immunohistochemical staining of mouse spleen using Caspase-4 antibody at 2 ug/ml.

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  Formalin-Fixed, Paraffin-Embedded Human Pancreas stained with Caspase-4 antibody at 5 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 µg/ml.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: 16 amino acid peptide from the amino-terminus of Human Caspase-4. Epitope: N-Terminus.
• Specificity: This antibody recognizes 16 amino acid peptide from the amino-terminus of Human Caspase-4
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 4 (CASP4), transcript variant alpha
• Database Link:
  Entrez Gene 12363 MouseEntrez Gene 837 Human
• Background: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease. The rodent homolog is known as Caspase 4 and Caspase 11.
• Synonyms: CASP4, ICH2, ICE(rel)-II, Protease ICH-2, Protease TX

Reference Data

• Protein Families: Druggable Genome, Protease