Caspase 4 (CASP4) Rabbit Polyclonal Antibody

CAT#: AP22938PU-N

Caspase 4 (CASP4) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 2 µg/ml.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated
Specificity This antibody reacts to Caspase 4 (CASP4).
Formulation PBS containing 0.02% sodium azide.
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens caspase 4 (CASP4), transcript variant alpha
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease. The rodent homolog is known as Caspase 4 and Caspase 11.
Synonyms CASP4, ICH2, ICE(rel)-II, Protease ICH-2, Protease TX
Reference Data
Protein Families Druggable Genome, Protease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.