Caspase-7 (CASP7) (N-term) Rabbit Polyclonal Antibody

CAT#: AP22940PU-N

Caspase-7 (CASP7) (N-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of caspase-7 in human skeletal muscle cell lysate with caspase-7 antibody at (A) 0.5 and (B) 1 ug/ml.

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  Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 0.5 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CASP7 antibody was raised against synthetic peptide - KLH conjugated
• Specificity: This antibody reacts to Caspase 7 (CASP7).
• Formulation: PBS containing 0.02% sodium azide.
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 7 (CASP7), transcript variant a
• Database Link:
  Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 840 Human
• Background: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.
• Synonyms: CASP-7, CASP7, MCH3, CMH-1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Alzheimer's disease, Apoptosis