SPI1 (27-37) Goat Polyclonal Antibody

CAT#: AP22967PU-N

SPI1 (27-37) goat polyclonal antibody, Aff - Purified

Product Images

Colon, lymphoid aggregate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Bovine, Canine, Equine, Human, Porcine, Rabbit
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human SPI1 / PU.1 (NP_001074016.1; NP_003111.2)
• Specificity: This antibody reacts to the internal region of Spi-1 Proto-oncogene (SPI1).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA and 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens Spi-1 proto-oncogene (SPI1), transcript variant 2
• Database Link:
  Entrez Gene 6688 Human
• Background: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
• Synonyms: Transcription factor PU.1, SPI-1 proto-oncogene, SFPI1

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer