TXNRD1 (600-612) Goat Polyclonal Antibody

CAT#: AP23024PU-N

TXNRD1 (600-612) goat polyclonal antibody, Aff - Purified

Product Images

Western Blot Image: Antibody staining (0.1 ug/ml) of Human Placenta lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

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  Immunohistochemistry Image: Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunohistochemistry Image: Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/32000.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot: 1/32000, 0.1 - 1 µg/ml.
• Reactivities: Canine, Human, Monkey, Porcine
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human TXNRD1
• Specificity: This antibody detects Thioredoxin reductase 1 (TXNRD1) (C-term).
  It is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens thioredoxin reductase 1 (TXNRD1), transcript variant 5
• Database Link:
  Entrez Gene 7296 Human
• Background: TRXR1 / TXNRD1 is a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination.
• Synonyms: KDRF, GRIM-12

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pyrimidine metabolism