FOXA2 (453-463) Goat Polyclonal Antibody

CAT#: AP23027PU-N

FOXA2 (453-463) goat polyclonal antibody, Aff - Purified

Product Images

Western Blot Image: Antibody staining (1 ug/ml) of Human Liver lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

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  Immunohistochemistry Image: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/2000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
  Western Blot: 1-3 µg/ml.
• Reactivities: Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Xenopus
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human FOXA2
• Specificity: This antibody detects FOXA2 / HNF3B (C-term).
  This antibody is expected to recognize both reported isoforms.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens forkhead box A2 (FOXA2), transcript variant 1
• Database Link:
  Entrez Gene 15376 MouseEntrez Gene 25099 RatEntrez Gene 3170 Human
• Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).
• Synonyms: HNF-3-beta, HNF-3B, TCF3B

Reference Data

• Protein Families: Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young