Dynamin 3 (DNM3) Goat Polyclonal Antibody

CAT#: AP23062PU-N

Dynamin 3 (DNM3) goat polyclonal antibody, Purified

Product Images

Dynamin-3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Adrenal.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/1000.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of Human Dynamin-3 (DNM3).
• Specificity: Recognizes Dynamin-3 (DNM3).
• Formulation: Tris Saline Buffer, pH 7.3 containinbg 0.5% BSA as stabilizer and 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens dynamin 3 (DNM3), transcript variant 2
• Database Link:
  Entrez Gene 26052 Human
• Background: Dynamin 3 is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Dynamin 3 is most probably involved in vesicular trafficking processes, in particular endocytosis.
  The dynamins are a family of 100 kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin 1 is expressed exclusively in neurons, Dynamin 2 is ubiquitously expressed, and Dynamin 3 is thought to be restricted to expression in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.
• Synonyms: DNM3, KIAA0820, T-dynamin

Reference Data

• Protein Pathways: Endocytosis, Fc gamma R-mediated phagocytosis