TGF beta 3 (TGFB3) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23075PU-N

TGF beta 3 (TGFB3) (C-term) rabbit polyclonal antibody, Purified

Product Images

Formalin-Fixed, Paraffin-Embedded Human Brain, cerebellum stained with TGF-beta-3 Antibody Cat.-No AP23075PU-N at 5 ug/ml after heat-induced antigen retrieval.

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  Formalin-Fixed, Paraffin-Embedded Human Small Intestine stained with TGF-beta-3 Antibody Cat.-No AP23075PU-N at 5 ug/ml after heat-induced antigen retrieval.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Immunoprecipitation.
  Western Blot.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the C-terminus of the precursor form of human TGF beta 3
• Specificity: This antibody recognizes TGF-beta-3 at ~47kDa.
• Formulation: 10mM PBS, pH 7.4
  State: Purified
  State: Liquid purified IgG fraction
  Stabilizer: BSA
  Preservative: Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens transforming growth factor beta 3 (TGFB3), transcript variant 1
• Database Link:
  Entrez Gene 21809 MouseEntrez Gene 25717 RatEntrez Gene 7043 Human
• Background: Transforming Growth Factor beta 3 (TGF beta 3) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. A high level of TGF beta 3 in normal adult heart, lung, and brain suggests a possible role for this factor in the regulation of a variety of normal physiological functions. The expression of TGF beta 3 in different locations and at specific stages of embryogenesis suggests its involvement in the regulation of development. Similar to the other isoforms of TGF beta, the upregulated activation of TGF beta 3 might also be involved in a variety of pathological conditions. TGF beta 3 has been detected in human, porcine, and avian sources and is expressed in cells of mesenchymal origin, suggesting a different role for this protein than for TGF beta 1 or TGF beta 2. TGF beta 3 is less prevalent in natural expression than either TGF beta 1 or TGF beta 2, but is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord and in several human carcinoma cells.
• Synonyms: Transforming growth factor beta-3

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway