HTR2C Rabbit Polyclonal Antibody

CAT#: AP23092PU-N

HTR2C rabbit polyclonal antibody, Purified

Product Images

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide containing a sequence corresponding to a region within amino acids 387 and 446 of Human 5HT2C Receptor.
• Specificity: This antibody detects Human Serotonin receptor 2C (HTR2C).
  Other species not tested.
• Formulation: 0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C), transcript variant 2
• Database Link:
  Entrez Gene 3358 Human
• Background: 5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity.
• Synonyms: HTR1C, 5HT-1C, 5-hydroxytryptamine receptor 2C, 5-HTR2C, 5-HT-2C, 5-HT2C

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction