SPI1 (1-122) Rabbit Polyclonal Antibody
Other products for "SPI1"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | SPI1 / PU.1 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 122 of Human PU.1 |
Specificity | This antibody detects SPI1 / PU.1 at aa 1-122. |
Formulation | PBS, pH 7, 40% Glycerol, 0.01% Thimerosal State: Aff - Purified State: Liquid Ig fraction |
Concentration | 1 mg/ml |
Purification | Immunoaffinity Chromatography |
Gene Name | Homo sapiens Spi-1 proto-oncogene (SPI1), transcript variant 2 |
Database Link | |
Background | Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing. |
Synonyms | Transcription factor PU.1, SPI-1 proto-oncogene, SFPI1 |
Reference Data | |
Protein Families | Transcription Factors |
Protein Pathways | Acute myeloid leukemia, Pathways in cancer |
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