SPI1 (1-122) Rabbit Polyclonal Antibody

CAT#: AP23158PU-N

SPI1 (1-122) rabbit polyclonal antibody, Aff - Purified

Product Images

Sample (30 ug of whole cell lysate). A: Hela. 12% SDS PAGE. SPI1 antibody diluted at 1:1000.

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: SPI1 / PU.1 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 122 of Human PU.1
• Specificity: This antibody detects SPI1 / PU.1 at aa 1-122.
• Formulation: PBS, pH 7, 40% Glycerol, 0.01% Thimerosal
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens Spi-1 proto-oncogene (SPI1), transcript variant 2
• Database Link:
  Entrez Gene 366126 RatEntrez Gene 6688 Human
• Background: Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.
• Synonyms: Transcription factor PU.1, SPI-1 proto-oncogene, SFPI1

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Pathways in cancer