CD71 (TFRC) (169-377) Rabbit Polyclonal Antibody

CAT#: AP23167PU-N

CD71 (TFRC) (169-377) rabbit polyclonal antibody, Purified

Product Images

Sample (30 ug of whole cell lysate). A: Hep G2. B: Molt-4. C: Raji. 7.5% SDS PAGE. TFRC antibody diluted at 1:1000.

• 

  Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. CD71 antibody. TFRC antibody diluted at 1:1000.

• 

  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 169 and 377 of CD71.
  Amino acid sequence homology: Cat (86%), Dogs (81%), Pig (82%).
• Specificity: This antibody detects CD71 / TFRC at aa 169-377.
• Formulation: PBS, pH 7.0, 40% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.01% Thimerosal
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens transferrin receptor (TFRC), transcript variant 2
• Database Link:
  Entrez Gene 22042 MouseEntrez Gene 7037 Human
• Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity.
• Synonyms: TfR1, p90, Transferrin receptor protein 1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Endocytosis, Hematopoietic cell lineage