Factor X (F10) Sheep Polyclonal Antibody

CAT#: AP23181PU-N

Factor X (F10) sheep polyclonal antibody, Aff - Purified

Product Images

Small intestine, vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Liver, vessel: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, ID, Ie, IHC
• Recommended Dilution: ELISA.
  Immunodiffusion.
  Immunoelectrophoresis.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Human Factor X purified from plasma, activated and active site blocked
• Specificity: This antibody detects Coagulation factor X (F10).
  Affinity purified IgG was analyzed by immunoelectrophoresis. Only one arc was seen with normal plasma. No arc was seen with Factor X deficient plasma.
• Formulation: 10mM HEPES, pH 7.4, 0.15M Sodium Chloride, 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens coagulation factor X (F10), transcript variant 1
• Database Link:
  Entrez Gene 2159 Human
• Background: F10 is the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting.
• Synonyms: Stuart factor, Stuart-Prower factor

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Complement and coagulation cascades