VASP Rabbit Polyclonal Antibody

CAT#: AP23202PU-N

VASP rabbit polyclonal antibody, Aff - Purified

Product Images

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 20 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Canine, Equine, Human, Monkey, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthesized non-phosphopeptide derived from human VASP around the phosphorylation site of serine 157
• Specificity: This antibody detects endogenous levels of total VASP protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Purification: Immunoaffinity Chromatography
• Storage: Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens vasodilator-stimulated phosphoprotein (VASP)
• Database Link:
  Entrez Gene 22323 MouseEntrez Gene 361517 RatEntrez Gene 7408 Human
• Background: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
• Synonyms: Vasodilator-stimulated phosphoprotein

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration