Tau (MAPT) Rabbit Polyclonal Antibody

CAT#: AP23205PU-N

Tau (MAPT) rabbit polyclonal antibody, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/500 - 1/1000.
Reactivities Bovine, Canine, Chicken, Goat, Human, Monkey, Mouse, Rabbit, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 422
Specificity This antibody detects endogenous levels of total MAPT / TAU.
Formulation PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Immunoaffinity chromatography
Storage Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens microtubule associated protein tau (MAPT), transcript variant 6
Background Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU.
Synonyms MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, MAPK signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.