GRB2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23211PU-N

GRB2 (C-term) rabbit polyclonal antibody, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Western Blot: 1 µg/ml.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen GRB2 antibody was raised against synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217).
Specificity The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kD adaptor protein.
Formulation PBS containing 15 mM sodium azide and 0.2% BSA
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1
Background Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.
Synonyms Growth factor receptor-bound protein 2
Reference Data
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Renal cell carcinoma, T cell receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.