gamma Catenin (JUP) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23241PU-N

gamma Catenin (JUP) (N-term) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: At 1μg/ml with the appropriate system to detect Catenin γ in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect Catenin γ in formalin fixed and paraffin embedded tissues.
  Immunocytochemistry.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the N-terminal of human Cateninγ
• Specificity: This antibody detects Junction plakoglobin at N-term. No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens junction plakoglobin (JUP), transcript variant 1
• Database Link:
  Entrez Gene 16480 MouseEntrez Gene 81679 RatEntrez Gene 3728 Human
• Background: Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
• Synonyms: Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer