GFAP (C-term) Rabbit Polyclonal Antibody

CAT#: AP23244PU-N

GFAP (C-term) rabbit polyclonal antibody, Aff - Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Western blot: 0.1-0.5 µg/ml.
Immunohistochemistry on Paraffin Sections: 0.5-1 µg/ml. 
Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a sequence at the C-terminal (417-432aa) of Human GFAP.
Specificity This antibody detects GFAP at C-term. No cross reactivity with other proteins.
Formulation 0.2 mg Na2HPO4, 0.9 mg NaCl
State: Aff - Purified
State: Lyophilized purified IgG fraction
Stabilizer: 5 mg BSA
Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
Reconstitution Method 0.2 ml of distilled water will yield a concentration of 0.5 mg/ml.
Purification Immunoaffinity Chromatography
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens glial fibrillary acidic protein (GFAP), transcript variant 2
Background GGlial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.
Synonyms Glial Fibrillary Acidic Protein
Reference Data
Protein Families ES Cell Differentiation/IPS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.