DUT Rabbit Polyclonal Antibody
Other products for "DUT"
Specifications
Product Data | |
Applications | IHC, IP, WB |
Recommended Dilution | Western blot: At 0.5-1μg/ml with the appropriate system to detect dUTPase in cells and tissues. Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect dUTPase in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Immunoprecipitation. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a sequence mapping at the middle region of human dUTPase |
Specificity | This antibody detects DUT in the middle. No cross reactivity with other roteins. |
Formulation | 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg himerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction |
Reconstitution Method | 0.2ml of distilled water will yield a concentration of 500μg/ml. |
Purification | Immunogen affinity purified |
Storage | Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens deoxyuridine triphosphatase (DUT), transcript variant 1 |
Database Link | |
Background | Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is responsible for maintaining low ntracellular levels of dUTP, thus preventing the incorporation of dUTP into DNA. DUTPase ctivity/expression can be down-regulated using siRNA specifically targeted to dUTPase mRNA and UTPase plays a role in DNA nucleotide metabolism. This protein, present predominantly in the ytoplasm, contains 252 amino acids with a Mr of 26,704. It exhibits 35% identity with the E. coli UTPase and 53% identity with the Saccharomyces cerevisiae enzyme. The nuclear and mitochondrial orms of dUTPase are encoded by the same gene with isoform-specific transcripts arising through the se of alternative 5-prime exons. Human dUTPase exhibits 92% identity with rat. Moreover, this nzyme has profound effects on the efficacy of agents that target thymidylate biosynthesis. |
Synonyms | dUTPase, dUTP pyrophosphatase |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, Pyrimidine metabolism |
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