INSL3 (N-term) Rabbit Polyclonal Antibody

CAT#: AP23273PU-N

INSL3 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin embedded Human testicle sections, staining INSL3 in cytoplasm DAB chromogenic reaction

Specifications

Product Data

• Applications: IF, IHC, IP, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect INSL3 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect INSL3 in formalin fixed and paraffin embedded tissues.
  Immunoprecipitation.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence near the N-terminal of human INSL3
• Specificity: This antibody detects INSL3 / RLF (N-term).
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens insulin like 3 (INSL3), transcript variant 2
• Database Link:
  Entrez Gene 3640 Human
• Background: Insulin-like 3 (INSL3), a member of the insulin-like hormone superfamily, is specifically expressed in Leydig cells of the fetal and postnatal testis and in theca cells of the postnatal ovary. It is synthesized as a 131-amino acid preproprotein, which contains a 24-amino acid signal peptide. The human INSL3 gene is assigned to bands p13.2-p12 of the short arm of chromosome 19 with the similar organization to that of insulin and relaxin. INSL3 induces gubernaculum development in an androgen-independent way, while androgen-mediated regression of the CSL occurs independently from Insl3. Moreover,INSL3 is a ligand for LGR8 and INSL3-LGR8 mutations are believed to be associated with human cryptorchidism.
• Synonyms: RLNL, Insulin-like 3, Leydig insulin-like peptide, Relaxin-like factor

Reference Data

• Protein Families: Druggable Genome, Secreted Protein