Mitofusin 2 (MFN2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23274PU-N

Mitofusin 2 (MFN2) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat cardiac muscle tissue lysis using MFN antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence mapping at the N-terminal of human MFN2
• Specificity: This antibody detects Mitofusin-2 at N-term.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Gene Name: Homo sapiens mitofusin 2 (MFN2), transcript variant 2
• Database Link:
  Entrez Gene 64476 RatEntrez Gene 170731 MouseEntrez Gene 9927 Human
• Background: Mitofusin 2 (MFN2) is a mitochondrial transmembrane GTPase regulating mitochondrial fusion and that the nucleotide-dependent activation of MFN2 concomitantly protects the organelle from permeability transition. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. It is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. This protein contains an N-terminal GTPase domain and a transmembrane domain near the C terminus. It shares 60% identity with MFN1. When stably expressed in COS-7 cells, MFN2 colocalizes with mitochondrial markers. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.
• Synonyms: MFN2, CPRP1, KIAA0214

Reference Data

• Protein Families: Transmembrane