CCR7 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23283PU-N

CCR7 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of spleen sections using CCR7 antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect CCR7 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect CCR7 in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to a sequence mapping at the C-terminal of human CCR7
• Specificity: This antibody detects CD197 / CCR7 at C-term. No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens chemokine (C-C motif) receptor 7 (CCR7)
• Database Link:
  Entrez Gene 12775 MouseEntrez Gene 287673 RatEntrez Gene 1236 Human
• Background: Schweickart et al.identified CCR7(also known as EBI1) in 1994, which is a lymphoid-specific member of the G protein-coupled receptor family. This gene, which is encoded on human chromosome 17q12-q21.2, is expressed in normal lymphoid tissues and in several B-and T-lymphocyte cell lines with 86% identity to the mouse homolog. It is also related to the receptors that recognize chemoattractants, such as interleukin-8, RANTES, C5a, and fMet-Leu-Phe. Expression of CCR7 controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets.
• Synonyms: C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EVI1, BLR2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction