CCR5 (N-term) Rabbit Polyclonal Antibody

CAT#: AP23286PU-N

CCR5 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat liver tissue lysis using CCR5 antibody

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  Immunohistochemical analysis of paraffin embedded rectal carcinoma sections, staining CCR5 in cytoplasm, DAB chromogenic reaction

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: Use at 0.5-1 μg/ml with the appropriate system to detect CCR5 in cells and tissues.
  Immunohistochemistry on Paraffin Sections: Use at 0.5 mg-2 μg/ml to detect CCR5 in formalin fixed and paraffin embedded tissues.
  Boiling Sections is recommended.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence at the N-terminal of Human CCR5
• Specificity: This antibody detects CD195 / CCR5 (N-term).
• Formulation: 0.9 mg NaCl, 0.2 mg Na2HPO4
  State: Aff - Purified
  State: Lyophilized purified Ig fraction
  Stabilizer: 5 mg BSA
  Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
• Reconstitution Method: Restore with 0.2 ml of distilled water to a concentration of 0.5 mg/ml.
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens C-C motif chemokine receptor 5 (gene/pseudogene) (CCR5), transcript variant A
• Database Link:
  Entrez Gene 12774 MouseEntrez Gene 117029 RatEntrez Gene 1234 Human
• Background: Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.
• Synonyms: C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis