BAX (N-term) Rabbit Polyclonal Antibody

CAT#: AP23289PU-N

BAX (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Hela cell lysis using BAX antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect BAX in cells and tissues.
• Reactivities: Human, Mouse, Rabbit, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence mapping near the N-terminal of human BAX
• Specificity: This antibody detects Bax near N-term. No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens BCL2-associated X protein (BAX), transcript variant beta
• Database Link:
  Entrez Gene 12028 MouseEntrez Gene 24887 RatEntrez Gene 581 Human
• Background: BAX (Bcl-2 Associated X Protein) is a member of the Bcl-2 gene family, it encodes a 21-kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. Human BAX gene is located in the q13.3-q13.4 region of human chromosome 19. Bax is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. Bax is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane (alpha) and two forms of cytosolic protein (beta and gamma). BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. They are critical mediators of B cell death induced by multiple stimuli.
• Synonyms: Apoptosis regulator BAX, BCL2L4, Bcl2-L-4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Huntington's disease, Neurotrophin signaling pathway, p53 signaling pathway, Pathways in cancer, Prion diseases