MMP14 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23330PU-N

MMP14 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

MMP14 Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 0.5-1μg/ml with the appropriate system to detect MMP14 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 1-2 μg/ml to detect MMP14 in formalin fixed and paraffin embedded tissues.
  Immunohistochemistry on frozen sections: At 1-2 μg/ml to detect MMP14 in formalin or acetone fixed tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide mapping at the C-terminal of human MMP14
• Specificity: This antibody detects MMP-14 (C-term).
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens matrix metallopeptidase 14 (MMP14)
• Database Link:
  Entrez Gene 17387 MouseEntrez Gene 81707 RatEntrez Gene 4323 Human
• Background: Matrix metalloproteinases (MMPs) are Zn(2+)-binding endopeptidases that degrade various components of the extracellular matrix (ECM). The MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. MMPs have different substrate specificities and are encoded by different genes. membrane-type matrix metalloproteinase (MMP14) may be an activator of pro-gelatinase A (MMP2) and is expressed in fibroblast cells during both wound healing and human cancer progression. Survivin, MMP2, MMP9, and MMP14 mRNA expression levels in clinically aggressive pigmented lesions were significantly higher than those in normal eutopic endometrium, and survivin gene expression in pigmented lesions was also higher than that in nonpigmented lesions (P less than 0.05). There was a close correlation between survivin and MMP2, MMP9, and MMP14 gene expression levels in 63 endometriotic tissues examined (P less than 0.01).
• Synonyms: Matrix metalloproteinase-14, MMP14, MMP-X1, Membrane-type-1 matrix metalloproteinase

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: GnRH signaling pathway