TIMP3 (C-term) Rabbit Polyclonal Antibody

CAT#: AP23357PU-N

TIMP3 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of rat kidney tissue lysis using TIMP3 antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect TIMP-3 in cells and tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A peptide mapping at the C-terminal end of TIMP-3 of human origin
• Specificity: This antibody detects TIMP3 (C-term). No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens TIMP metallopeptidase inhibitor 3 (TIMP3)
• Database Link:
  Entrez Gene 21859 MouseEntrez Gene 25358 RatEntrez Gene 7078 Human
• Background: The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD).
• Synonyms: Protein MIG-5, TIMP-3

Reference Data

• Protein Families: Druggable Genome, Secreted Protein