Secretogranin 3 (SCG3) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23363PU-N

Secretogranin 3 (SCG3) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis of paraffin-embedded rat tissue sections (brain), staining SCDG3 in cytoplasm, DAB chromogenic reaction

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: At 1-2μg/ml with the appropriate system to detect SCG3 in cells and tissues.
  Immunohistochemistry on paraffin sections: At 0.5-1μg/ml to detect SCG3 in formalin fixed and paraffin embedded tissues.
  Immunohistochemistry on frozen sections: At 0.5-1μg/ml to detect SCG3 in formalin or acetone fixed tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a sequence near the C-terminal of human SCG3
• Specificity: This antibody detects Secretogranin-3 (SCG3) at C-term. No cross reactivity with other proteins.
• Formulation: 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
  State: Aff - Purified
  State: Lyophilized Ig fraction
• Reconstitution Method: 0.2ml of distilled water will yield a concentration of 500μg/ml.
• Purification: Immunogen affinity purified
• Gene Name: Homo sapiens secretogranin III (SCG3), transcript variant 1
• Database Link:
  Entrez Gene 20255 MouseEntrez Gene 116635 RatEntrez Gene 29106 Human
• Background: SCG3 (secretogranin Ⅲ) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. SCG3 was the only gene within a haplotype block that contained rs3764220. SCG3 mRNA and immunoreactivity were detected in the paraventricular nucleus, lateral hypothalamic area, and arcuate nucleus, and the protein coexisted with orexin, melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin. SCG3 formed a granule-like structure together with these neuropeptides.
• Synonyms: Secretogranin III, Sg-III, SgIII

Reference Data

• Protein Families: Druggable Genome, Secreted Protein