PLGF (PGF) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23368PU-N

PLGF (PGF) (N-term) rabbit polyclonal antibody, Aff - Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution Western blot: At 1-2μg/ml with the appropriate system to detect PLGF in cells and tissues.
Immunohistochemistry on paraffin sections: At 1-2μg/ml to detect PLGF in formalin fixed and paraffin embedded tissues.
Immunocytochemistry.
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a sequence mapping near the N-terminal of human PLGF
Specificity This antibody detects Placenta growth factor / PGF (N-term). No cross reactivity with other proteins.
Formulation 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 1.2% sodium acetate or neutral PBS. If 0.5ml of PBS is used, the
antibody concentration will be 100μg/ml.
Purification Immunogen affinity purified
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens placental growth factor (PGF), transcript variant 1
Background Placental growth factor (PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors (VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter-and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.
Synonyms PGFL, PLGF, PlGF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Bladder cancer, Focal adhesion, mTOR signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.