Caspase 2 (CASP2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP23372PU-N

Caspase 2 (CASP2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Caspase 2 Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: Use 1 μg/ml with the appropriate system to detect Caspase 2 in cells and tissues.
  Immunohistochemistry on Paraffin Sections: A previous lot of this antibody has been used at 1-2 μg/ml to detect Caspase 2 in formalin fixed and paraffin embedded tissues.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide mapping at the C-terminal of Human Caspase 2
• Specificity: This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
• Formulation: 0.9 mg NaCl, 0.2 mg Na2HPO4
  State: Aff - Purified
  State: Lyophilized purified Ig fraction
  Stabilizer: 5 mg BSA
  Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
• Reconstitution Method: 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20 °C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 1
• Database Link:
  Entrez Gene 12366 MouseEntrez Gene 64314 RatEntrez Gene 835 Human
• Background: Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
• Synonyms: CASP-2, CASP2, ICH1, ICH-1 protease, NEDD2

Reference Data

• Protein Families: Druggable Genome, Protease